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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
12.42
Human Site:
S45
Identified Species:
22.78
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
S45
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
Chimpanzee
Pan troglodytes
P61584
1003
117506
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
S181
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
Dog
Lupus familis
XP_540083
1519
175559
Q176
A
S
P
R
F
S
R
Q
R
V
D
G
L
N
S
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
S45
R
S
P
I
N
V
E
S
L
L
D
G
L
N
S
Rat
Rattus norvegicus
Q62868
1379
159417
V45
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
M45
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
Chicken
Gallus gallus
XP_419954
1438
166280
G94
L
P
S
S
L
P
A
G
A
M
D
G
L
N
S
Frog
Xenopus laevis
NP_001154860
1372
159002
F45
S
I
V
L
D
L
D
F
P
A
L
R
K
N
K
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
F45
A
L
V
L
D
L
D
F
P
A
L
R
K
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
S50
D
T
E
G
H
Q
F
S
L
D
Y
L
L
D
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
D24
I
N
I
E
S
L
L
D
T
I
T
A
L
V
N
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
S45
I
T
T
H
R
L
S
S
H
D
F
Q
M
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
0
100
46.6
N.A.
100
13.3
N.A.
6.6
33.3
6.6
6.6
N.A.
20
N.A.
6.6
6.6
P-Site Similarity:
100
0
100
53.3
N.A.
100
26.6
N.A.
20
40
33.3
33.3
N.A.
46.6
N.A.
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
0
8
0
8
16
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
16
0
16
8
0
24
39
16
0
8
0
% D
% Glu:
0
0
8
8
0
8
24
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
8
16
0
0
8
0
8
0
0
% F
% Gly:
0
0
8
8
0
0
0
8
0
8
8
39
0
0
0
% G
% His:
0
0
0
8
8
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
16
8
8
24
0
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
24
% K
% Leu:
24
8
0
24
8
31
16
0
39
24
24
8
62
0
0
% L
% Met:
0
0
8
0
8
0
0
8
0
8
0
0
8
0
0
% M
% Asn:
0
8
0
0
31
0
0
0
0
0
0
0
0
54
16
% N
% Pro:
0
8
31
0
0
8
0
0
24
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
8
0
8
0
0
0
8
0
0
0
% Q
% Arg:
24
0
0
8
8
0
8
0
8
0
0
16
0
0
0
% R
% Ser:
8
31
8
8
8
16
8
39
0
0
0
0
0
0
39
% S
% Thr:
0
16
8
0
0
0
0
0
8
0
8
0
0
0
8
% T
% Val:
0
0
16
8
0
24
0
8
0
8
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _